Fluorocytosine (5-Fluorocytosine)
| Chemical Name |
Fluorocytosine (5-Fluorocytosine) |
| CAS Number |
2022-85-7 |
| Product Number |
SA000008 |
| Molecular Formula |
C4H4FN3O |
| Molecular Weight |
129.0924632 |
5-Fluorocytosine is a fluorinated cytosine analog that is used as an antifungal agent.
Flucytosine is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
Specification
Appearance White to Off-white crystalline powder
Assay 99%-101%
Residue on ignition 0.1% max
Fluorouracil 0.1% max
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